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Reconstituted standards were prepared using methylated HepG2.2.15 BS DNA and HepG2 BS DNA

Key genes modulated by GHK-Cu include: Genes encoding growth factors (FGF, VEGF, TGF-) Collagen and extracellular matrix proteins (COL1A1, COL3A1, ELN) Anti-inflammatory and antioxidant enzymes (SOD, catalase) Cell adhesion and communication molecules Collagen & Extracellular Matrix Synthesis Collagen synthesis is fundamental to GHK-Cu's regenerative effects

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For example, studies in mice using gut microbial metabolites that restore intestinal barrier function and reduce inflammatory cytokines also resulted in lower BP [96]

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